Monday, October 25, 2010

Evaluation of Bone Marrow- and Brain-Derived Neural Stem Cells

In this study, published in 2010, researchers using a mouse model determine that neural stem cells (NSC) derived from bone marrow have the same theraputic effect as those derived from the adult subventricular zone.
Here's an excerpt: 
"In the present study, we demonstrate that NSCs derived from bone marrow (BM) cells exhibit comparable morphological properties as those derived from SVZ cells and possess a similar ability to differentiate into neurons, astrocytes, and oligodendrocytes both in vitro and in vivo."
It appears the importance of this discovery, if it translates into humans, is that neural stem cells derived from bone marrow are as effective as those harvested from the brain. Because it is easier to harvest cells from bone marrow, this has positive implications for future therapies.

Here is a link to the study.

The authors are: Jingxian Yang, Yaping Yan, Bogoljub Ciric, Shuo Yu, Yangtai Guan, Hui Xu, Abdolmohamad Rostami and Guang-Xian Zhang.

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